Pyridinium chloride → 2,3-Dichloro-2',4-dihydroxybenzophenone

HRID 568686Notes

Reaction equation

HRID 568686 reaction equation
[Cl:1][C:2]1[C:17]([Cl:18])=[C:16]([O:19]C)[CH:15]=[CH:14][C:3]=1[C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[O:12]C)=[O:5].Cl.N1C=CC=CC=1>>[Cl:1][C:2]1[C:17]([Cl:18])=[C:16]([OH:19])[CH:15]=[CH:14][C:3]=1[C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[OH:12])=[O:5]

Participants

3

Reactant 2

HCID 10176127Pyridinium chlorideHCID 140125702,3-Dichloro-2',4-dimethoxybenzophenone

Product 1

HCID 128540642,3-Dichloro-2',4-dihydroxybenzophenone

Conditions

Temperature
200 °C

Procedure

A solid mixture of 13 g of 2,3-dichloro-2',4-dimethoxybenzophenone and 52 g of pyridine HCl is heated at 200° C. for one hour. The hot mixture is then poured into vigorously stirred ice water. The product is extracted with ethyl acetate. The extract is dried over Na2SO4 and evaporated to give 2,3-dichloro-2',4-dihydroxybenzophenone, mp 197°-201° C.

Workup

  1. extractionThe product is extracted with ethyl acetate
  2. dry with materialThe extract is dried over Na2SO4
  3. customevaporated

Sources & evidence

ORD record
ord-0a008d6ddfa34149aa5307a49fcc12fb
Source dataset
uspto-grants-1988_03
Patent number
US04728662

Reaction notes

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