2,3-Dichloroanisole → HCID 20150508, compound

HRID 568688Notes

Reaction equation

HRID 568688 reaction equation
[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][CH:5]=[CH:4][C:3]=1[O:9]C.[F:11][C:12]1[CH:13]=[C:14]([CH:18]=[CH:19][CH:20]=1)[C:15](Cl)=[O:16].[Al+3].[Cl-].[Cl-].[Cl-]>>[Cl:8][C:7]1[C:2]([Cl:1])=[C:3]([OH:9])[CH:4]=[CH:5][C:6]=1[C:15]([C:14]1[CH:18]=[CH:19][CH:20]=[C:12]([F:11])[CH:13]=1)=[O:16]

Participants

4

Reactant 3

HCID 161262,3-DichloroanisoleHCID 743763-Fluorobenzoyl chlorideHCID 6451240Aluminum(III) Chloride

Product 1

HCID 20150508HCID 20150508, compound

Procedure

The Friedel-Crafts reaction described in the foregoing examples is repeated with 2,3-dichloroanisole, 3-fluorobenzoyl chloride and AlCl3 to yield 2,3-dichloro-4-hydroxy-3'-fluorobenzophenone.

Workup

  1. customThe Friedel-Crafts reaction

Sources & evidence

ORD record
ord-f7403e1788304b8abf20748907bd3b73
Source dataset
uspto-grants-1988_03
Patent number
US04728662

Reaction notes

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