Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Nitrogen | HCID 947 | — |
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | HCID 136393692 | HCID 136393692 | — |
| Product | HCID 14012511 | HCID 14012511 | — |
Reaction Steps
To a solution of 3 g of 2,3-dichloro-4-hydroxy-3'-fluorobenzophenone oxime in 20 ml of DMF, 0.25 g of NaH is added in an atmosphere of N2. The mixture is stirred for 18 hours. The mixture is heated to 100° C. for one hour. The reaction mixture is poured into ice water to yield 7-chloro-3-(3-fluorophenyl)-6-methoxy-1,2-benzisoxazole, mp 149°-150° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04728662 |
|---|
| Source dataset | uspto-grants-1988_03 |
|---|
| ORD ID | ord-1a959c86282944cbab2d444977bb4170 |
|---|
| Source note | uspto-grants-1988_03 |
|---|
