HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 2-{[3-(4-Chlorophenyl)-1,2-benzisoxazol-6-yl]oxy}butyric acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Ethyl 2-{[3-(4-chlorophenyl)-1,2-benzisoxazol-6-yl]oxy}butyrate | HCID 14012534 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-{[3-(4-Chlorophenyl)-1,2-benzisoxazol-6-yl]oxy}butyric acid | HCID 14012535 | — |
Reaction Steps
A solution of 3.6 g of ethyl-2-{[3-(4-chlorophenyl)-1,2-benzisoxazol-6-yl]oxy}butyrate, 30 ml of 15% sodium hydroxide solution and 30 ml of methanol, is stirred under reflux for 3 hr. The methanol is evaporated and the solution is poured into dilute hydrochloric acid/ice affording a flocculate precipitate. The precipitate is collected, dried in vacuo and recrystallized from toluene to afford 2-{[3-(4-chlorophenyl)-1,2-benzisoxazol-6-yl]oxy}butyric acid, mp 144° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04728662 |
| Source dataset | uspto-grants-1988_03 |
| ORD ID | ord-4de55766d5b24938bcb00afc641824ed |
| Source note | uspto-grants-1988_03 |