反应详情

温度

210 °C

A mixture of 60 g of pyridine hydrochloride and 12.0 g 3-(4-chlorophenyl)-6-methoxy-1,2-benzisoxazole is heated with stirring at 210° C. for 75 min. The hot reaction mixture is poured with vigorous stirring onto ice and the solid is filtered, dried, and recrystallized from toluene to afford 3-(4-chlorophenyl)-6-hydroxy-1,2-benzisoxazole, mp 203° C.

1. temperatureis heated
2. additionThe hot reaction mixture is poured
3. stirringwith vigorous stirring onto ice
4. filtrationthe solid is filtered
5. customdried
6. customrecrystallized from toluene