1,2-Dichloroethane → HCID 20150388, compound

Participants

Reaction Steps

3,4,5-Trimethoxybenzoyl chloride (6.7 g, 0.029 mol) was added dropwise to a solution composed of 7.0 g (0.0241 mol) of 3,4-dihydro-7-methoxy-2-methyl-2-[2-(piperazin-1-yl)ethyl]-2H-benzopyran, 2.28 g of pyridine and 100 ml of 1,2-dichloroethane. The resultant mixture was stirred at room temperature for 2 hours. The reaction mixture obtained was poured into water and extracted with diethyl ether, the extract was dried over anhydrous sodium sulfate, and low-boiling substances were distilled off under reduced pressure. The residue was purified by silica gel column chromatography to give 5.0 g of 1-[2-(3,4-dihydro-7-methoxy-2-methyl-2H-benzopyran-2-yl)ethyl]-4-(3,4,5-trimethoxybenzoyl)piperazine [Compound (25)] having the following physical characteristics.

Provenance & Evidence