HCID 20150397, compound → HCID 20150385, compound

Participants

Reaction Steps

A solution composed of 2.0 g of the 3,4-dihydro-6-methoxy-2-[2-[4-(3-methyl-2-butenyl)piperazin-1-yl]ethyl]-2,5,7,8-tetramethyl-2H-benzopyran obtained by the process of Example 13, 0.1 g of 5% palladium on carbon and 50 ml of ethanol was stirred at room temperature for 48 hours. The reaction mixture was filtered to remove the palladium on carbon and low-boiling substances were distilled off under reduced pressure. The residue was purified by silica gel column chromatography to give 1.24 g of 1-[2-(3,4-dihydro-6-methoxy-2,5,7,8-tetramethyl-2H-benzopyran-2-yl)ethyl]-4-isopentylpiperazine [Compound (34)] having the following physical characteristics.

Provenance & Evidence