Water → HCID 54027108, compound

Participants

Reaction Steps

Optically active p-(1-methyl-heptyloxy)phenol (50.0 g, 0.22 mol) was dissolved in pyridine (300 ml), followed by dropwise adding to the solution, a solution of p-benzyloxybenzoic acid chloride (50.0 g, 0.20 mol) prepared above in (ii), dissolved in toluene (300 ml), under ice cooling, agitating the mixture for 2 hours while keeping it at about 50°~60° C., allowing it to stand overnight, thereafter adding toluene (1,500 ml) and water (1,000 ml), agitating the mixture, washing the toluene layer with 6N-HCl, then with 2N-NaOH aqueous solution and further with water until the wash water became neutral, distilling off toluene, and recrystallizing the residue from ethanol to obtain optically active p-benzyloxybenzoic acid p-(1-methyl-heptyloxy)phenyl ester (69.0 g).

Provenance & Evidence