HCID 20149423, compound → HCID 178429218, compound

Participants

Reaction Steps

Analogously to Example 5, 4.50 g. (0.014 mole) 6-trifluoroacetamido-5-nitro-3,3-dimethylindolin-2-one in 500 ml. ethanol are hydrogenated in the presence of 0.5 g. 10% palladium on charcoal at normal pressure and at ambient temperature. After filtration, the filtrate is evaporated to dryness in a vacuum and the residue is dissolved in dichloromethane/ethyl acetate and treated with active charcoal. After filtration, the filtrate is evaporated to dryness in a vacuum and the residue is recrystallised from ethyl acetate, there being obtained 3.8 g. (95% of theory) of the title compound in the form of the monohydrate; m.p. 175°-177° C.

Provenance & Evidence