1,1'-Carbonyldiimidazole → HCID 178481587, compound

Participants

Reaction Steps

9.8 g. 1,1'-Carbonyldiimidazole are added to 6.1 g. 6-amino-5-methylamino-3,3-dimethylindolin-2-one in 250 ml. dioxan and the reaction mixture is heated under reflux for 2 hours. The solution is evaporated to dryness in a vacuum and the reddish oil remaining behind is boiled under reflux for 2 hours with 20% aqueous hydrochloric acid. The mixture is cooled to ambient temperature and neutralised with aqueous ammonia solution, while cooling with ice. The precipitate is filtered off with suction and recrystallised from methanol. There are obtained 2.0 g. of the title compound; m.p. 364°-367° C.

Provenance & Evidence