HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperazine → Sarafloxacin
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperazine | HCID 4837 | — |
| Reactant | 7-Chloro-6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid | HCID 57338 | — |
| Product | Sarafloxacin | HCID 56208 | — |
Reaction Steps
In the described fashion as Example 1(e), the above acid (7) R6 =H, R=p-fluorophenyl), after reacting with the piperazine, can give the desired 1-p-fluoro-phenyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)quinoline-3-carboxylic acid (9) ##STR17## R=p-fluorophenyl) and its hydrochloride salt.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04730000 |
| Source dataset | uspto-grants-1988_03 |
| ORD ID | ord-a2bc4f42b32b4c059a13d274628e928d |
| Source note | uspto-grants-1988_03 |