HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperazine → 3-Quinolinecarboxylic acid, 1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperazine | HCID 4837 | — |
| Reactant | N-(2,4-difluorophenyl)-6-fluoro-7-chloro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid | HCID 11484989 | — |
| Product | 3-Quinolinecarboxylic acid, 1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)- | HCID 464873 | — |
Reaction Steps
In the described fashion as Example 1(e), the above acid (7) (R6 =H, R=2,4-difluorophenyl), after reacting with piperazine, can give the described 1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-7-(piperazinyl)quinoline-3-carboxylic acid (9) ##STR19## R=2,4-difluorophenyl) and its hydrochloride salt.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04730000 |
| Source dataset | uspto-grants-1988_03 |
| ORD ID | ord-398dd4c4760b4e0882a581fa22d9ccc7 |
| Source note | uspto-grants-1988_03 |