Thiomorpholine → HCID 10668222, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 3.36 g of 7 chloro-1-p-fluoro-phenyl-6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid (the product of Example 4(b)) in 35 ml of 1-methyl-2-pyrrolidinone at 115° C. is added 4.13 g of thiomorpholine. After stirring at 115° C. for 20 hours, the solvent is removed by reduced pressure to dryness. Methanol is added to the residue and the resulting mixture is filtered and washed with ethylacetate and then washed with water. The solid is dried, yielding 2.51 g 1-p-fluorophenyl-6-fluoro-1,4-dihydro-4-oxo-7-thiomorpholino-quinoline-3-carboxylic acid (9) ##STR36## R=p-fluorophenyl) in 62% yield.

Provenance & Evidence