3-Acetamidopyrrolidine → HCID 20149301, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 1.5 g 7-chloro-1-phenyl-6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid (product of Example 1(d)) in 20 ml of 1-methyl-2-pyrrolidinone at 115° C. is added 3 g of 3-acetamido-pyrrolidine. After stirring at 100° C. for 20 hours, the solvent is removed by reduced pressure to dryness. Ethanol is added to the residue and washed with ether and then diluted cold hydrochloric acid and then water. The solid is dried, yielding 1.60 g 1-phenyl-6-fluoro-1,4-dihydro-4-oxo-7-(3-acetamido-1-pyrrolidinyl)-quinoline-3-carboxylic acid (9) ##STR43## R-phenyl).

Provenance & Evidence