Water → 6-Oxohexanoic acid

HRID 568867Notes

Reaction equation

HRID 568867 reaction equation
[CH:1]([CH2:3][CH2:4][CH2:5][CH2:6][C:7]([O:9]C)=[O:8])=[O:2].O>CO>[CH:1]([CH2:3][CH2:4][CH2:5][CH2:6][C:7]([OH:9])=[O:8])=[O:2]

Participants

4

Reactant 2

HCID 962WaterHCID 81164Methyl 6-oxohexanoate

Product 1

HCID 4409186-Oxohexanoic acidYield 74%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

36 g of methyl 5-formylvalerate, 90 g of water and 2 g of cation exchanger which consisted of crosslinked polystyrene containing sulfo groups were refluxed for 8.5 hours, the methanol formed being distilled off constantly. Fractional distillation under reduced pressure gave 24 g (74% of theory) of 5-formylvaleric acid.

Workup

  1. additioncontaining sulfo groups
  2. temperaturewere refluxed for 8.5 hours
  3. distillationbeing distilled off constantly
  4. distillationFractional distillation under reduced pressure

Sources & evidence

ORD record
ord-81c0abb62eeb4ba0ace1da1191a8307a
Source dataset
uspto-grants-1988_03
Patent number
US04730040

Reaction notes

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