反应详情

A solution of the product of stage (ii) (4.60 g) in absolute ethanol (75 ml) was hydrogenated at room temperature and atmospheric pressure over a pre-reduced 10% palladium oxide on carbon catalyst (1 g, 50% paste in water) in absolute ethanol (25 ml). The catalyst was removed by filtration through `hyflo` and the solvent evaporated in vacuo at 40° to yield the title compound as a colourless oil (3.0 g). T.l.c. (T-ET-A 39:10:1) Rf 0.32.

1. customwas hydrogenated at room temperature
2. customThe catalyst was removed by filtration through `hyflo` and the solvent
3. customevaporated in vacuo at 40°