HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 568971Generated: October 26, 2026
Trimethylsilyl cyanide → 4-Benzyloxy-2-fluorobutyronitrile
https://huagongshe.com/reaction/568971
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Trimethylsilyl cyanide | HCID 82115 | — |
| Reactant | (Diethylamino)sulfur trifluoride | HCID 123472 | — |
| Reactant | 3-(Benzyloxy)propanal | HCID 10888261 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-Benzyloxy-2-fluorobutyronitrile | HCID 20149458 | — |
Reaction Steps
Under nitrogen, a mixture of trimethylsilyl cyanide (1.335 mL, 10 mmoles) and 15 (1.64 g, 10 mmoles) is heated at 100° C. for 6 hours. The reaction is monitored by NMR (88% conversion after 6 hours). The mixture is cooled to 5° C. (ice bath), and CH2Cl2 (12 mL) is added, followed by diethylaminosulfurtrifluoride, (0.46 g, 9.1 mmoles), dissolved in CH2Cl2 (8 mL) at about 5° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04730006 |
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| Source dataset | uspto-grants-1988_03 |
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| ORD ID | ord-1717436c494c46e3b4f296899bbbec3b |
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| Source note | uspto-grants-1988_03 |
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