Trimethylsilyl iodide → HCID 20149471, compound

Participants

Reaction Steps

Compound 18 prepared above (20.0 g, 56 mmoles) is dissolved in dry dichloromethane (Baker Blue Label) and treated with trimethylsilyliodide (11.2 g, 56 mmoles) overnight under nitrogen. The mixture is washed with NaHCO3, then with water, dried, and evaporated. The oil obtained, 19, is purified by filtration over silica, washing first with pet. ether (3 L), then with ethyl acetate: 15 g (about quantitative).

Provenance & Evidence