HCID 57219958, compound → HCID 18611974, compound

Participants

Reaction Steps

3-fluoro-2,6-di-tert.-butoxycarbonylaminopimelic acid (940 mg, 2.3 mmoles) is dissolved in ether saturated with HCl gas, and the mixture is stirred overnight. The white crystals are filtered off and dissolved in isopropanol/ethanol. After filtration through a membrane filter (Millipore), propylene oxide (0.6 mL) is added. The precipitate is stirred with isopropanol and filtered off again. Crystallization from water/ethanol/isopropanol gives the pure title compound (100 mg) containing 0.2 moles of HCl.

Provenance & Evidence