Hydrochloric Acid → 3-Phthalimido-4,4-difluoro-7-hydroxy-1-heptene

Beteiligte Stoffe

Reaktionsschritte

Under an atmosphere of nitrogen, a mixture of 3-phthalimido-4,4-difluoro-7-methoxy-1-heptene (440 mg, 1.43 mmoles) and trimethylsilyliodide (400 mg, 2 mmoles) in dry dichloromethane (10 ml) is heated overnight under reflux. 1N HCl (10 ml) is added to the reaction mixture which is kept under vigorous stirring for 1/2 hour. The organic layer is separated, washed successively with water, sodium bisulfite solution, and water, and is dried over sodium sulfate. 3-phthalimido-4,4-difluoro-7-hydroxy-1-heptene is obtained as a solid: 3.85 mg (91%).

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