HCID 20149485, compound → HCID 20149486, compound

Participants

Reaction Conditions

Reaction Steps

Under an atmosphere of nitrogen, vinyl magnesium bromide (1 ml of 1M solution in tetrahydrofuran) is added to 4,4-difluoro-5-phthalimido-6-hepten-1-al (274 mg, 0.93 mmoles), dissolved in dry tetrahydrofuran (5 ml) previously cooled to -70° C. The temperature is allowed to rise to -5° C., and the reaction mixture is quenched with a saturated solution of ammonium chloride, diluted with ether, and the layers are separated. The alcohol obtained as an oil (300 mg) is purified by chromatography on silica (ethyl acetate/petroleum ether: 70/30, RF: 0.61): 148 mg (49%).

Provenance & Evidence