HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phthalimide → HCID 20149445, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phthalimide | HCID 6809 | — |
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | ethyl N-ethoxycarbonyliminocarbamate | HCID 220568 | — |
| Reactant | HCID 20149486 | HCID 20149486 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 20149445 | HCID 20149445 | — |
Reaction Steps
A mixture of 3-hydroxy-6,6-difluoro-7-phthalimido-1,8-nonadiene (148 mg, 0.46 mmoles), phthalimide (73.5 mg, 0.5 mmoles), triphenylphosphine (131.5 mg, 0.5 mmoles) and diethyl azodicarboxylate (73 l, 0.6 mmoles) in tetrahydrofuran (5 ml) is kept under nitrogen at 25° C. for 20 hours. After concentration under reduced pressure, the title compound is obtained after purification by chromatography on silica (dichloromethane, RF: 0.43): 95 mg (46%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04730006 |
| Source dataset | uspto-grants-1988_03 |
| ORD ID | ord-f32b1760e7c0413f85497921899d8062 |
| Source note | uspto-grants-1988_03 |