Bromine → HCID 13059708, compound

Participants

Reaction Steps

Dissolve 7-chlorothiochroman-4-one (10 g., 50.3 mmole) in chloroform (100 mL) and cool the solution to 0°-5° C. Add bromine (2.60 mL, 50.3 mmole) dropwise over a 10-minute period. Stir the reaction mixture at room temperature for one hour, then add chloroform (100 mL) and extract with 10% aqueous sodium sulfite (100 mL) followed by water (200 mL). Dry the chloroform solution over anhydrous magnesium sulfate, filter and evaporate in vacuo to a residue. Recrystallize the residue from cyclohexane to give 3-bromo-7-chlorothiochroman-4-one, mp 109°-110° C.

Provenance & Evidence