Sodium borohydride → HCID 13059709, compound

Participants

Reaction Steps

Suspend 3-bromo-7-chlorothiochroman-4-one (59.6 g., 215 mmole) in methanol (500 mL), cool to 0°-5° C., and with stirring add sodium borohydride (8.18 g., 215 mmole) in three portions. After stirring the reaction mixture at room temperature for three hours, pour it into ice water (4 liters) and extract with chloroform (2 liters). Dry the chloroform solution over anhydrous magnesium sulfate, filter and evaporate in vacuo to a residue. Triturate the residue with chloroform/hexane to give 3-bromo-7-chlorothiochroman-4-ol, mp 141°-142° C.

Provenance & Evidence