Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dimethylformamide dimethyl acetal → 3,9-Dimethyl-beta-carboline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dimethylformamide dimethyl acetal | HCID 78373 | — |
| 반응물 | 3-Methyl-9h-pyrido[3,4-b]indole | HCID 13315103 | — |
| 반응물 | Diazabicyclooctane | HCID 66583054 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 3,9-Dimethyl-beta-carboline | HCID 13315104 | — |
반응 단계
0.182 g of 3-methyl-β-carboline (example 5), 0.5 ml of N,N-dimethylformamide-dimethylacetal (90%) and 0.02 g of diazabicyclooctane (Dabco) are stirred in 30 ml of absolute N,N-dimethylformamide for 15 hours at 110° C. The solvent is distilled off under vacuum and the residue is chromatographed on silica gel. (Methylene chloride/ethanol: 9+1). 0.095 g of 3,9-dimethyl-β-carboline with a 134° C. melting point (decomposition) is obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04731358 |
| 출처 데이터셋 | uspto-grants-1988_03 |
| ORD ID | ord-b8750ec4c71049779173d6fd74688f96 |
| 출처 메모 | uspto-grants-1988_03 |