Acetic Anhydride → HCID 13315120, compound

HRID 569029Notes

Reaction equation

HRID 569029 reaction equation
[NH2:1][C:2]1[N:3]=[CH:4][C:5]2[NH:6][C:7]3[C:12]([C:13]=2[CH:14]=1)=[CH:11][CH:10]=[CH:9][CH:8]=3.[C:15](OC(=O)C)(=[O:17])[CH3:16]>N1C=CC=CC=1>[NH:1]([C:2]1[N:3]=[CH:4][C:5]2[NH:6][C:7]3[C:12]([C:13]=2[CH:14]=1)=[CH:11][CH:10]=[CH:9][CH:8]=3)[C:15]([CH3:16])=[O:17]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 1195373-Aminonorharman

Product 1

HCID 13315120HCID 13315120, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

2 g of 3-amino-β-carboline are suspended in 35 ml of pyridine and mixed with 4 ml of acetic anhydride. The aminocarboline dissolves during slight heating. After 20 minutes the solution is evaporated. The crystalline residue is washed with water and is recrystallized from ethyl acetate. Yield: 1.5 g of 3-acetamino-β-carboline with a 200°-203° C. melting point.

Workup

  1. dissolutionThe aminocarboline dissolves during slight heating
  2. customAfter 20 minutes the solution is evaporated
  3. washThe crystalline residue is washed with water
  4. customis recrystallized from ethyl acetate
  5. customwith a 200°-203° C.

Sources & evidence

ORD record
ord-648ff060109347f393dc92e0e0108fdd
Source dataset
uspto-grants-1988_03
Patent number
US04731358

Reaction notes

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