Isoamyl Nitrite → HCID 13315128, compound

Participants

Reaction Conditions

Reaction Steps

732 mg of 3-amino-β-carboline in 7 ml of diethyldisulfide are heated to 80° C. and mixed with 1 ml of isoamylnitrite. After 0.5 hours of heating to 80° C., it is again mixed with 1 ml of isoamylnitrite and heated to 80° C. for 1.5 hours. After distilling off, the residue is chromatographed twice on silica gel with ethyl acetate/cyclohexane as eluant. After absorptive precipitation of the corresponding evaporated fraction with cyclohexane/diisopropyl ether, 206 mg of 3-ethylthio-β-carboline with a 132°-133° C. melting point are obtained.

Provenance & Evidence