Diethylamine → HCID 86742039, compound

Participants

Reaction Steps

A mixture of 0.2 g of 5-benzyloxy-β-carboline-3-phosphonic acid diethyl ester (example 61) and 0.1 g of oxalyl chloride in 10 ml of dichloromethane is stirred for 24 hours at room temperature and then mixed with an excess of diethylamine. It is heated to boiling for 2 more hours for completion of the reaction. It is diluted with acetic acid and extracted with water. The evaporation residue of the organic phase yields 0.15 g of the title compound after crystallization from tetrahydrofuran.

Provenance & Evidence