HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 569060Generated: October 25, 2026
Hydrochloric Acid → 2-Sulfamoylthieno[3,2-c]pyridin-4(5H)-one
https://huagongshe.com/reaction/569060
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 4-Chlorothieno[3,2-c]pyridine-2-sulfonamide | HCID 20148583 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2-Sulfamoylthieno[3,2-c]pyridin-4(5H)-one | HCID 20148557 | 66% |
Reaction Steps
A solution of 2-sulfamoyl-4-chlorothieno[3,2-c]pyridine (0.87 g, 3.5 mmol) in 10 N sodium hydroxide (1.8 ml) diluted with water (7 ml) was heated at 100° C. for 5-10 hours. After cooling the reaction and acidification with concentrated hydrochloric acid, the precipitated product was collected by filtration. Recrystallization from hot dimethyl sulfoxide by dilution with ethanol gives 0.53 g (66% yield) of product; m.p. 299°-301° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04731368 |
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| Source dataset | uspto-grants-1988_03 |
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| ORD ID | ord-ef57163a5e684e049f1b51872253b2cb |
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| Source note | uspto-grants-1988_03 |
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