Acetic Anhydride → HCID 20148554, compound

Participants

Reaction Steps

A mixture of the product from Step A (10.75 g, 0.038 mol) and 50 ml of acetic anhydride was heated at reflux for 16 hours. After removal of the acetic anhydride in vacuo, the residue was heated in 6 N hydrochloric acid (50 ml) for 3 hours. The cooled reaction mixture was diluted with water (400 ml), chilled and the resulting solid was filtered, washed with water and dried, 5.25 g (60% yield). Recrystallization from water gave 2-sulfamoylthieno[2,3-b]pyridin-6(7H)-one; m.p. 306°-308° C.

Provenance & Evidence