Hydrochloric Acid → 3-Cyano-2-oxo-8-chromenyloxyacetic acid

Participants

Reaction Steps

Ten ml of tetrahydrothiophene was cooled with ice, to which 13.4 g of pulverized anhydrous aluminium bromide was gradually added. After stirring for 5 minutes, a temperature was brought to room temperature and then a solution of 2.6 g of 3-cyano-2-oxo-8-chromenyloxyacetic acid methyl ester dissolved in 30 ml of methyl chloride was gradually added. After stirring for 2 hours, the reaction mixture was poured into a mixture of 20 ml of concentrated hydrochloric acid and 200 ml of ice water and a precipitate was filtered, which was recrystallized to give a desired compound.

Provenance & Evidence