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Methyl iodide → 4-[N-(4-Chloro-benzyl)-methylamino]-cyclohexanol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl iodide | HCID 6328 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 4-(4-Chloro-benzylamino)-cyclohexanol | HCID 13670658 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 4-[N-(4-Chloro-benzyl)-methylamino]-cyclohexanol | HCID 13670660 | — |
反応手順
7.2 g (30 mMol) of 4-[N-(4-chloro-benzyl)-amino]-cyclohexanol are dissolved in 30 ml of dimethyl-formamide, and after the addition of 2.2 g (16 mMol) of potassium carbonate, 4.26 g (30 mMol) of methyliodide are added dropwise. When the slightly exothermic reaction has ended, the mixture is concentrated by evaporation, mixed with water and extracted with chloroform. The concentrated extracts are chromatographed on silica gel to purify them (eluant; methylene chloride/methanol=20/1).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04731374 |
| 出典データセット | uspto-grants-1988_03 |
| ORD ID | ord-cf350ff17b494516829bc7e2dc5d9f47 |
| 出典メモ | uspto-grants-1988_03 |