Benzoyl chloride → HCID 13670754, compound

HRID 569106Notes

Reaction equation

HRID 569106 reaction equation
[NH2:1][C:2]1[S:3][C:4]2[CH2:10][CH:9]([N:11]([CH3:13])[CH3:12])[CH2:8][CH2:7][C:5]=2[N:6]=1.[C:14]([Cl:22])(=[O:21])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>N1C=CC=CC=1>[ClH:22].[ClH:22].[C:14]([NH:1][C:2]1[S:3][C:4]2[CH2:10][CH:9]([N:11]([CH3:13])[CH3:12])[CH2:8][CH2:7][C:5]=2[N:6]=1)(=[O:21])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

Participants

4

Reactant 2

HCID 7412Benzoyl chlorideHCID 13670672HCID 13670672, compound

Product 1

HCID 13670754HCID 13670754, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

3.0 g (15 mMol) of 2-amino-6-dimethylamino4,5,6,7-tetrahydro-benzthiazole are dissolved in 15 ml of pyridine and 2.1 g (15 mMol) of benzoylchloride are added dropwise. After standing overnight the mixture is concentrated, mixed with soda solution and extracted with chloroform. The chloroform extract is concentrated and then chromatographed on silica gel (eluant: methylenechloride/methanol=9/1). The isolated base (melting point 174° C.) is dissolved in acetone and the dihydrochloride is precipitated with isopropanolic hydrochloric acid.

Workup

  1. concentrationthe mixture is concentrated
  2. additionmixed with soda solution
  3. extractionextracted with chloroform
  4. extractionThe chloroform extract
  5. concentrationis concentrated
  6. customchromatographed on silica gel (eluant: methylenechloride/methanol=9/1)
  7. dissolutionThe isolated base (melting point 174° C.) is dissolved in acetone
  8. customthe dihydrochloride is precipitated with isopropanolic hydrochloric acid

Sources & evidence

ORD record
ord-321179090a9d4a27b8c43fc82e72ef8e
Source dataset
uspto-grants-1988_03
Patent number
US04731374

Reaction notes

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