Pyridine → HCID 67882217, compound

HRID 569134Notes

Reaction equation

HRID 569134 reaction equation
[Cl:1][CH2:2][CH2:3][NH:4][C:5]([O:7][CH2:8][C@@H:9]([CH2:12][O:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH3:31])[O:10][CH3:11])=[O:6].[N:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1>>[Cl-:1].[CH3:11][O:10][C@H:9]([CH2:12][O:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH3:31])[CH2:8][O:7][C:5]([NH:4][CH2:3][CH2:2][N+:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1)=[O:6]

Participants

3

Reactant 2

HCID 1049PyridineHCID 18612287HCID 18612287, compound

Product 1

HCID 67882217HCID 67882217, compound

Conditions

Temperature
80 °C

Procedure

A solution of 0.035 g of (R)-1-O-[(2-chloroethyl)carbamoyl]-2-O-methyl-3-O-octadecylglycerine is treated with 5 ml of pyridine and heated at 80° C. for 3 days. The solution is evaporated and the residue is treated with toluene by azeotropic distillation. The residue is recrystallized from acetone. There is obtained 1-[2-[1-[(R)-2-methoxy-3-(octadecyloxy)propoxy]formamido]ethyl]pyridinium chloride of melting point 65° C. (dec.).

Workup

  1. customThe solution is evaporated
  2. additionthe residue is treated with toluene by azeotropic distillation
  3. customThe residue is recrystallized from acetone

Sources & evidence

ORD record
ord-0a63cf3206d345e78b1bac4bcd30feb5
Source dataset
uspto-grants-1988_03
Patent number
US04731373

Reaction notes

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