Methanol → HCID 13362007, compound

Participants

Reaction Conditions

Reaction Steps

To 42.1 gm. of methyl 1-benzyl-2-(3-methoxyphenyl)-5-oxopyrrolidin-3-carboxylate in 436 ml. of absolute methanol was slowly added at -10° to -5°, 37.9 gm. of sodium borohydride. The reaction mixture was left in the ice bath until it came to ambient temperature. Concentration in vacuo provided a white gum which was suspended in water and heated to 50° C. The gum was extracted with chloroform, dried (Na2SO4), filtered, and concentrated in vacuo to yield 22.8 gm. of yellow oil.

Provenance & Evidence