Acetic Acid → HCID 14098152, compound

Participants

Reaction Steps

2,3-Dichloro-4-(4-chlorobutyryl)anisole (28.1 g, 0.1 mole), dimethylamine hydrochloride (36.7 g, 0.45 mole) and paraformaldehyde (7.65 g, 0.255 mole) were united and glacial acetic acid (2.6 ml) added. The mixture was stirred and heated on a steam bath under anhydrous conditions for 2 hours. Then the mixture was treated with N,N-dimethylformamide and heating and stirring on a steam bath continued for another 2 hours. The mixture was poured into a mixture of crushed ice and water (800 ml) and extracted with ether.

Provenance & Evidence