Acetic Acid → HCID 14098152, compound

Participants

Reaction Steps

2,3-Dichloro-4-(4-chlorobutyryl)anisole (28.1 gm, 0.1 mole), dimethylamine hydrochloride (36.7 mg, 0.45 mole), paraformaldehyde (7.65 gm, 0.255 mole) and acetic acid (2.6 ml) were united, stirred and heated on a steam bath for 2 hours. N,N-dimethylformamide (100 ml) was added and the stirring and heating was continued for another two hours. The mixture was then poured into ice diluted to 800 ml with water and extracted with ether. The combined extracts were washed with water, dried over MgSO4 and evaporated in vacuo to give 14.2 gm of product, m.p. 58°-60° C.

Provenance & Evidence