HCID 14098152, compound → HCID 14099847, compound

Participants

Reaction Steps

2,3-Dichloro-4-(4-chloro-2-methylenebutyryl)anisole (14 gm, 0.037 mole) was dissolved in methylene chloride (7 ml) and added with stirring concentrated to sulfuric acid (55 ml) over a period of 20 minutes. The temperature rose to 39° C. The mixture was stirred for 16 hours at ambient temperature, then poured into ice water, extracted first with methylene chloride and then with ether. The combined organic extracts were washed with water, dried over MgSO4 and evaporated in vacuo. The residue (12 gm) was triturated with isopropyl alcohol, filtered and dried to give the product, m.p. 103°-105° C.

Provenance & Evidence