8alpha-(3,3-Diethylureido)-6-methylergoline-2-carboxylic acid → 1,1-Diethyl-3-(2,6-dimethyl-8alpha-ergolinyl)urea

HRID 569319Notes

Reaction equation

HRID 569319 reaction equation
[CH2:1]([N:3]([CH2:27][CH3:28])[C:4](=[O:26])[NH:5][C@H:6]1[CH2:20][C@H:19]2[C@@H:9]([CH2:10][C:11]3[C:21]4[C:14](=[CH:15][CH:16]=[CH:17][C:18]2=4)[NH:13][C:12]=3[C:22](O)=O)[N:8]([CH3:25])[CH2:7]1)[CH3:2]>CO>[CH3:22][C:12]1[NH:13][C:14]2[C:21]3[C:11]=1[CH2:10][C@@H:9]1[C@@H:19]([C:18]=3[CH:17]=[CH:16][CH:15]=2)[CH2:20][C@H:6]([NH:5][C:4](=[O:26])[N:3]([CH2:27][CH3:28])[CH2:1][CH3:2])[CH2:7][N:8]1[CH3:25]

Participants

3

Reactant 1

HCID 135590348alpha-(3,3-Diethylureido)-6-methylergoline-2-carboxylic acid

Product 1

HCID 140110111,1-Diethyl-3-(2,6-dimethyl-8alpha-ergolinyl)urea

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

8α-(3,3-diethylureido)-6-methylergoline-2-carboxylic acid, yield: 48%, [α]D =+27° (0.2% in methanol).

Sources & evidence

ORD record
ord-efe6698614554d6a8220e317024d149d
Source dataset
uspto-grants-1988_03
Patent number
US04731367

Reaction notes

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