HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydro-2-(2-propynyloxy)-2H-pyran → 3-[9,10-Didehydro-6-methyl-2-[3-(tetrahydropyran-2-yloxy)-1-propynyl]-8alpha-ergolinyl]-1,1-diethylurea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydro-2-(2-propynyloxy)-2H-pyran | HCID 98609 | — |
| Reactant | 3-(2-Bromo-6-methyl-8alpha-ergolinyl)-1,1-diethylurea | HCID 13059860 | — |
| Product | 2-Methyl-3-butyn-2-ol | HCID 8258 | — |
| Product | 3-[9,10-Didehydro-6-methyl-2-[3-(tetrahydropyran-2-yloxy)-1-propynyl]-8alpha-ergolinyl]-1,1-diethylurea | HCID 70395575 | 25% |
Reaction Steps
Starting with 3-(2-bromo-6-methyl-8α-ergolinyl)-1,1-diethylurea, 3-(tetrahydropyran-2-yloxy)-1-propyne yields 3-[9,10-didehydro-6-methyl-2-[3-(tetrahydropyran-2-yloxy)-1-propynyl]-8α-ergolinyl]-1,1-diethylurea (25%) and 3-hydroxy-3-methyl-1-butyne yields 3-[9,10-didehydro-2-(3-hydroxy-3-methyl-1-butynyl)-6-methyl-8α-ergolinyl]-1,1-diethylurea (31%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04731367 |
| Source dataset | uspto-grants-1988_03 |
| ORD ID | ord-219f7ed9ddd141b48bd5784227ed205e |
| Source note | uspto-grants-1988_03 |