Ammonium fumarate → L-Aspartic Acid

HRID 569460Notes

Reaction equation

HRID 569460 reaction equation
[C:1]([O-:8])(=[O:7])/[CH:2]=[CH:3]/[C:4]([O-:6])=[O:5].[NH4+:9].[NH4+]>O>[NH2:9][C@H:2]([C:1]([OH:8])=[O:7])[CH2:3][C:4]([OH:6])=[O:5]

Participants

3

Reactant 1

HCID 9793847Ammonium fumarate2×

Product 1

HCID 5960L-Aspartic Acid

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A batch type process wherein the catalyst compositions are stirred in from 0.1 to 5.0 molar (preferably 0.5 to 2.0 molar) solutions of ammonium fumarate in water at 5.0 to 10.0 pH (preferably 7.5 to 9.5 pH) for periods of 1.0 to 100 hours (preferably 8 to 48 hours) at temperatures below 50° C. (preferably 20° to 40° C). Broadly from 0.05 to 50 g of immobilized cells, preferably from 1.0 to 15 g, are used per 1.0 mole of starting ammonium fumarate. After the conversion, the catalyst compositions may be removed by filtration or the equivalent for reuse in converting fresh batches of fumarate solutions. The product solutions are obtained in a form suitable for conventional processing to isolate the L-aspartic acid (acidification, precipitation, filtration, washing, recrystallization, drying).

Workup

  1. customAfter the conversion, the catalyst compositions may be removed by filtration
  2. customThe product solutions are obtained in a form suitable for conventional processing

Sources & evidence

ORD record
ord-35afb9037c9548eb9c718bd0cb2b0c06
Source dataset
uspto-grants-1988_03
Patent number
US04732851

Reaction notes

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