2-[4-(5-Chloro-2-cyanophenyl)-2-oxopyridin-1(2H)-yl]propanoic acid → HCID 178460014, compound

HRID 56948Notes

Reaction equation

HRID 56948 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:20]#[N:21])=[C:6]([C:8]2[CH:13]=[CH:12][N:11]([CH:14]([CH3:18])[C:15]([OH:17])=O)[C:10](=[O:19])[CH:9]=2)[CH:7]=1.[NH:22]1[C:26]([C:27]2[CH:33]=[CH:32][C:30]([NH2:31])=[CH:29][CH:28]=2)=[N:25][N:24]=[N:23]1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:20]#[N:21])=[C:6]([C:8]2[CH:13]=[CH:12][N:11]([CH:14]([CH3:18])[C:15]([NH:31][C:30]3[CH:32]=[CH:33][C:27]([C:26]4[NH:25][N:24]=[N:23][N:22]=4)=[CH:28][CH:29]=3)=[O:17])[C:10](=[O:19])[CH:9]=2)[CH:7]=1

Participants

3

Reactant 2

HCID 1176228502-[4-(5-Chloro-2-cyanophenyl)-2-oxopyridin-1(2H)-yl]propanoic acidHCID 178507471HCID 178507471, compound

Product 1

HCID 178460014HCID 178460014, compound

Procedure

65 mg (purity 83%, 0.18 mmol) of 2-[4-(5-chloro-2-cyanophenyl)-2-oxopyridin-1(2H)-yl]propanoic acid (racemate) (Example 2.2B) and 1.2 eq. of 4-(1H-tetrazol-5-yl)aniline were reacted according to General Method 1. Yield: 17 mg (22% of theory)

Sources & evidence

ORD record
ord-1d8b1c6056d44859b5a04000097a4b55
Source dataset
uspto-grants-2016_09
Patent number
US09434690B2

Reaction notes

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