1-Octyne → HCID 20147164, compound

HRID 569492Notes

Reaction equation

HRID 569492 reaction equation
Br[C:2]1[CH:3]=[C:4]([CH:7]=[O:8])[S:5][CH:6]=1.[CH:9]#[C:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16]>>[C:9]([C:2]1[CH:3]=[C:4]([CH:7]=[O:8])[S:5][CH:6]=1)#[C:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16]

Participants

3

Reactant 2

HCID 123701-OctyneHCID 877924-Bromothiophene-2-carbaldehyde

Product 1

HCID 20147164HCID 20147164, compoundYield 89%

Procedure

Reaction of 4-bromo-2-thiophenecarboxaldehyde (3.40 g 2 mmole, prepared by the methods described by D. Chadwick et al, J.C.S. Per 1 1766, 1973), with 1-octyne (4.40 g, 4 mmole) as described in Example 20 gave the title compound as a yellow oil (89.0%); mp 2° C.; νmax 3100, 2260, 1685, 1160, 855, 655, 622; δH(CDCl3) 0.88(3H, t, J=6 Hz), 1.3(8H, m), 2.33(2H, t, J=6 Hz), 7.7(2H, s), 9.9 (1H, s).

Workup

  1. customprepared by the methods

Sources & evidence

ORD record
ord-8fb0565ec0564f4a8089b45f4297a6d1
Source dataset
uspto-grants-1988_03
Patent number
US04732901

Reaction notes

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