2-[4-(5-Chloro-2-cyanophenyl)-2-oxopyridin-1(2H)-yl]propanoic acid → HCID 178494726, compound

HRID 56950Notes

Reaction equation

HRID 56950 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:20]#[N:21])=[C:6]([C:8]2[CH:13]=[CH:12][N:11]([CH:14]([CH3:18])[C:15]([OH:17])=O)[C:10](=[O:19])[CH:9]=2)[CH:7]=1.Cl.[CH3:23][O:24][CH2:25][C:26]1[N:30]=[C:29]([C:31]2[CH:37]=[CH:36][C:34]([NH2:35])=[CH:33][CH:32]=2)[NH:28][N:27]=1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:20]#[N:21])=[C:6]([C:8]2[CH:13]=[CH:12][N:11]([CH:14]([CH3:18])[C:15]([NH:35][C:34]3[CH:33]=[CH:32][C:31]([C:29]4[NH:28][N:27]=[C:26]([CH2:25][O:24][CH3:23])[N:30]=4)=[CH:37][CH:36]=3)=[O:17])[C:10](=[O:19])[CH:9]=2)[CH:7]=1

Participants

3

Reactant 2

HCID 1176228502-[4-(5-Chloro-2-cyanophenyl)-2-oxopyridin-1(2H)-yl]propanoic acidHCID 178494725HCID 178494725, compound

Product 1

HCID 178494726HCID 178494726, compound

Procedure

90 mg (purity 93%, 0.28 mmol) of 2-[4-(5-chloro-2-cyanophenyl)-2-oxopyridin-1(2H)-yl]propanoic acid (racemate) (Example 2.2B) and 80 mg (0.33 mmol) of 4-[3-(methoxymethyl)-1H-1,2,4-triazol-5-yl]aniline monohydrochloride were reacted according to General Method 1. Yield: 45 mg (33% of theory)

Sources & evidence

ORD record
ord-02ca262cdc3949f68c0fba581ab0f935
Source dataset
uspto-grants-2016_09
Patent number
US09434690B2

Reaction notes

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