HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-[4-(5-Chloro-2-cyanophenyl)-2-oxopyridin-1(2H)-yl]propanoic acid → 2-[4-(5-Chloro-2-cyanophenyl)-2-oxopyridin-1(2H)-yl]-N-[4-(1H-imidazol-4-yl)phenyl]propanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-[4-(5-Chloro-2-cyanophenyl)-2-oxopyridin-1(2H)-yl]propanoic acid | HCID 117622850 | — |
| Reactant | HCID 178507418 | HCID 178507418 | — |
| Product | 2-[4-(5-Chloro-2-cyanophenyl)-2-oxopyridin-1(2H)-yl]-N-[4-(1H-imidazol-4-yl)phenyl]propanamide | HCID 178460010 | — |
Reaction Steps
78 mg (0.25 mmol) of 2-[4-(5-chloro-2-cyanophenyl)-2-oxopyridin-1(2H)-yl]propanoic acid (racemate) (Example 2.2B) and 44 mg (0.28 mmol) of 4-(1H-imidazol-4-yl)aniline were reacted according to General Method 1. Yield: 40 mg (36% of theory)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09434690B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-94c1359c7130425eb4a8b469ac479f1b |
| Source note | uspto-grants-2016_09 |