HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Fluoroethanol → (3-propargyl-2,5-dioxo-1-imidazolidinyl)-methyl (1R,cis) 2,2-dimethyl-3-[(Z) 3-oxo-3-(2-fluoroethoxy)-1-propenyl]-cyclopropane-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Fluoroethanol | HCID 9737 | — |
| Reactant | 2,4-Imidazolidinedione, 3-(hydroxymethyl)-1-(2-propynyl)- | HCID 11789597 | — |
| Reactant | (1R,cis)2,2-dimethyl-3-[(Z)3-oxo-3-(2-fluoroethoxy)-1-propenyl]cyclopropane-carboxylic acid | HCID 86740321 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | (3-propargyl-2,5-dioxo-1-imidazolidinyl)-methyl (1R,cis) 2,2-dimethyl-3-[(Z) 3-oxo-3-(2-fluoroethoxy)-1-propenyl]-cyclopropane-carboxylate | HCID 86740320 | — |
Reaction Steps
Using the procedure of Step F of Example 9, (1R,cis)2,2-dimethyl-3-[(Z)3-oxo-3-(2-fluoroethoxy)-1-propenyl]cyclopropane-carboxylic acid prepared as in Example 21 except 2-fluoroethanol was used and (3-propargyl-2,5-dioxo-imidazolidinyl)-methanol were reacted to obtain (3-propargyl-2,5-dioxo-1-imidazolidinyl)-methyl(1R,cis)2,2-dimethyl-3-[(Z)3-oxo-3-(2-fluoroethoxy)-1-propenyl]-cyclopropane-carboxylate with a specific rotation of [α]D20 =+18°±2° (c=1% in CHCl3)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04732903 |
| Source dataset | uspto-grants-1988_03 |
| ORD ID | ord-44b15561b6884f898ab439459d8aa37b |
| Source note | uspto-grants-1988_03 |