Trifluoroacetic acid → HCID 117622826, 화합물

HRID 56959노트

반응식

HRID 56959 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[C:9]1[CH:14]=[CH:13][N:12]([CH:15]([CH3:32])[C:16]([NH:18][C:19]2[CH:31]=[CH:30][C:22]([C:23]([O:25]C(C)(C)C)=[O:24])=[CH:21][CH:20]=2)=[O:17])[C:11](=[O:33])[CH:10]=1.C(O)(C(F)(F)F)=O>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[C:9]1[CH:14]=[CH:13][N:12]([CH:15]([CH3:32])[C:16]([NH:18][C:19]2[CH:20]=[CH:21][C:22]([C:23]([OH:25])=[O:24])=[CH:30][CH:31]=2)=[O:17])[C:11](=[O:33])[CH:10]=1

참가 물질

3

반응물 2

HCID 6422Trifluoroacetic acidHCID 117622686tert-Butyl 4-({2-[4-(2-bromo-5-chlorophenyl)-2-oxopyridin-1(2H)-yl]propanoyl}amino)benzoate

생성물 1

HCID 117622826HCID 117622826, 화합물

실험 절차

96 mg (0.18 mmol) of tert-butyl 4-({2-[4-(2-bromo-5-chlorophenyl)-2-oxopyridin-1(2H)-yl]propanoyl}amino)benzoate (racemate) (Example 2.10C) were hydrolysed with TFA according to General Method 2. Yield: 69 mg (82% of theory)

출처 및 근거

ORD 기록
ord-f5b0053ca2534b1390fefa3def0f5cae
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09434690B2

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