Sodium Hydroxide → Disodium (phenoxymethylene)-bisphosphonate

HRID 569607Notes

Reaction equation

HRID 569607 reaction equation
[O:1]([CH:8]([P:13](=[O:16])([OH:15])[OH:14])[P:9](=[O:12])([OH:11])[OH:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+:18]>O>[O:1]([CH:8]([P:13](=[O:14])([O-:15])[O-:16])[P:9](=[O:10])([OH:11])[OH:12])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1.[Na+:18].[Na+:18]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 9816823(Phenoxymethylene)-bisphosphonic acid

Product 1

HCID 86742063Disodium (phenoxymethylene)-bisphosphonate

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of (phenoxymethylene)-bisphosphonic acid (53 g) in water (300 ml) was titrated with 2N sodium hydroxide to pH=5.5. The title compound was precipitated by the addition of acetone (1500 ml). The crystalline salt was filtered and washed with acetone. Drying in vacuo over potassium hydroxide at room temperature gave the title compound in the form of a tetrahydrate.

Workup

  1. customThe title compound was precipitated by the addition of acetone (1500 ml)
  2. filtrationThe crystalline salt was filtered
  3. washwashed with acetone
  4. dry with materialDrying in vacuo over potassium hydroxide at room temperature

Sources & evidence

ORD record
ord-29c7f82b119d495fa89189ceda44c7b4
Source dataset
uspto-grants-1988_03
Patent number
US04732998

Reaction notes

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