Iodomethyl pivalate → Tetra-(acetoxymethyl) (n-butoxymethylene)-bisphosphonate

HRID 569620Notes

Reaction equation

[O:1]([CH:8]([P:13](=[O:16])([OH:15])[OH:14])[P:9](=[O:12])([OH:11])[OH:10])[C:2]1[CH:7]=[CH:6][CH:5]=CC=1.[C:17]([O:23][CH2:24]I)(=[O:22])[C:18](C)(C)C>>[CH2:2]([O:1][CH:8]([P:13](=[O:16])([O:14][CH2:24][O:23][C:17](=[O:22])[CH3:18])[O:15][CH2:24][O:23][C:17](=[O:22])[CH3:18])[P:9](=[O:12])([O:10][CH2:24][O:23][C:17](=[O:22])[CH3:18])[O:11][CH2:24][O:23][C:17](=[O:22])[CH3:18])[CH2:7][CH2:6][CH3:5]

Participants

Reactant 2

HCID 104401Iodomethyl pivalate

HCID 9816823(Phenoxymethylene)-bisphosphonic acid

Product 1

HCID 54435735Tetra-(acetoxymethyl) (n-butoxymethylene)-bisphosphonate

Procedure

This compound was prepared as described in Example 51 by substituting (n-butoxymethylene)-bisphosphonic acid for (phenoxymethylene)-bisphosphonic acid and by substituting iodomethyl acetate for iodomethyl pivalate.

Workup

customThis compound was prepared

Sources & evidence

ORD record: ord-dd8b47404b304442a46953f8a906efad
Source dataset: uspto-grants-1988_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04732998

Reaction notes

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