HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 569637Generated: October 30, 2026
Benzylamine → (2E)-N-Benzyl-3-(3,4-dihydroxyphenyl)acrylamide
https://huagongshe.com/reaction/569637
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Benzylamine | HCID 7504 | — |
| Reactant | Dicyclohexylcarbodiimide | HCID 10868 | — |
| Reactant | Caffeic Acid | HCID 689043 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | (2E)-N-Benzyl-3-(3,4-dihydroxyphenyl)acrylamide | HCID 13644537 | — |
Reaction Steps
To 5 ml of tetrahydrofuran containing 180 mg of caffeic acid were added 206 mg of dicyclohexyl carbodiimide and 107 mg of benzylamine. The mixture was stirred at 50° C. for 6 hours and then filtrated. The filtrate was concentrated and the residue obtained was recrystallized from ethyl acetate/hexane to give 100 mg of granular crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04733002 |
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| Source dataset | uspto-grants-1988_03 |
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| ORD ID | ord-e12cb1269ee64004a28b81cd0e8f6276 |
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| Source note | uspto-grants-1988_03 |
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